【摘要】 N-（3’,4’,5’-三甲氧基肉桂酰）邻氨基苯甲酸（TOA）(100 mg·km^-1ip)显著抑制同系大鼠被动皮肤过敏反应（PCA）。剂量为 50和100 mg·kg^-1·d^-1,ip×4d时,明显抑制大鼠反相皮肤过敏反应（RCA）。致敏同时给药(50和100mg kg^-1·d^-1,ip×6d)或攻击前给药(100mg·kg^-1·d^-1,ip×2d),TOA对SRBC诱导的小鼠迟发型过敏反应（DTH）均有明显抑制作用。剂量为 50和100 mg·kg^-1ip时,TOA对大鼠皮内注时组胺及5-羟色胺（5-HT）引起的毛细血管通透性增加均有显著拮抗作用。更多还原

【Abstract】 Antiallergic effects of N-（3’,4’,5’-Trimethoxy cinnamoyl）Ortho-aminobenzoic acid（TOA）were stu-died in rats and mice. TOA(100mg. kg^-1. ip) inhibited 48h homologous passive cutaneous anaphylaxis（PCA） in rats. At the Dose of 50 or 100mg.kg^-1, ip for 4 or 6 days, TOA also significantly inhibi-ted reversed cutaneous anaphylaxis（RCA）in rats. and delayed type hypersinsitivity（DTH） to sheep redblood cells（SRBC）in normal mice. The studies also showed that TOA can markedly decrease the capil-lary permeability induced by histamine and 5-HT. The reslults indicate that it may be valuable to de-velop TOA as an antiallergic drug.更多还原