【摘要】 以肽6A灌流离体大鼠主动脉条,发现肽6A呈剂量依赖性抑制组织血管紧张素Ⅱ的合成和释放。肽6A和大鼠血浆体外孵育,明显地抑制血管紧张素转换酶(ACE)的活性。结果表明,肽6A具有ACE抑制作用。更多还原

【Abstract】 Peptide 6 A （P 6 A） is a fibrin （ogen） degradation product with various forms of bioactivity. Onthe model of isolated artery strip from rat aorta, it was found that perfusion with P 6 A (10^-6.-10^-4mol/L) significantly decreased vascular angiotensin （AGT） Ⅱ content in a dose-dependent manner（-18.6% to -23.2%）, and obviously inhibited AGT Ⅱ release from vessels（-18.1% to -39.8%）. Thein vitro incubation of P 6 A with rat blood plasma dramatically inhibited plasma angiotensin convertingenzyme （ACE） activity in a dose- and time-dependent manner. The results suggest that P 6 A inhibitsACE activity effectively.更多还原