【摘要】 用标准的微量淋巴细胞毒试验、62种人白细胞抗原（HLA）抗血清调查了61例弥漫性甲状腺肿伴甲状腺机能亢进症（Graves病）病人的HLA-A、HLA-B和HLA-Cw抗原.Graves病组的HLA-Bw₄₆抗原发生率（49.18%）显著高于对照组（5.31%）,相对危险率（RR）为17.903,相对危险率的显著性x²值为19.240（P<0.0001）.更多还原

【Abstract】 We used standard microdroplet Iymphocytotsicity test employing 62 HLA antisera to investigate HLA-A, -B, -Gw antigen frequencies in 61 patients with Graves’ disease. The frequency of HLA-Bw₄₆ showed a significant increase in the group of Graves’disease （49.18%） compared to normal controls （5.31%）. The relative risk （RR） for HLA-Bw₄₆ was 17.903. The X² value was 19.240 （P<0.0001）. These findings suggest a strong association between HLA-Bw₄₆ and Graves’ disease. The frequency of HLA-A₂₄ antigen tended to decrease significantly in patients with Graves’ disease as compared with controls, revealing a negative correlation.更多还原