【摘要】 用竞争性蛋白结合法和放射受体法观察了46例肾脏病患者血清维生素D代谢产物的变化。结果表明,各类肾脏病患者血清25-羟维生素D₃的含量均低于正常对照组,平均下降了41.2％（P<0.01）,以尿毒症患者最低,表明肾脏病患者维生素D的营养状态是低下的。尿毒症和肾病综合征患者,血清1,25-二羟维生素D₃[1,25（OH）₂D₃]亦明显下降,分别比对照组降低了33.5％和42.4％（P<0.05）,而慢性肾功能不全患者血清1,25（OH）₂D₃与肾功能不全的程度呈负相关。作者还对肾脏疾病维生素D代谢产物水平降低的机理进行了讨论。更多还原

【Abstract】 Alterations of serum vitamin D metabolites were observed by competitive protein-binding assay and radioreceptor assay in 46 patients with renal disease inckding chronic renal failure (CRF), nephrotic syndrcme (NS) and nephritis. The results indicated that serum 25-hydroxy-vitamin D (25-OHD) level decreased 41.2% as compared with the control group (P<0.01) and the lowest was found in uremic patients. It showed that vitamin D level is low in renal disease. Meanwhile serum 1,25-dihydroxy-vitamin D [1,25(OH)2D3] levels in uremia and NS patients decreased 33.5^ and 42.2% respectively (P<0.05) as compared with control group; serum l,.25(OH)2D3levels in CRF patients were negatively correlated with the severity of renal failure. The mechanism of low vitamin D metabolites in renal disease was discussed.更多还原