【摘要】 链脲佐菌素糖尿病大鼠及正常大鼠灌服吡磺环己脲10天后空腹血糖较服药前分别下降25.9％和40％,肝细胞胰岛素受体数目显著增加,空腹胰岛素水平无明显改变,胰岛素受体亲和力没有增高。提示吡磺环已脲的持续降血糖效应可能与增加胰岛素受体数目从而改善靶组织对胰岛素的敏感性有关。更多还原

【Abstract】 To determine whether glipizide has hypoglycemic effects at extrapancreatic sites, we have recently studied the effect of glipizide on hepatocyte insulin receptors of both streptozotocin (STZ)-induced diabetic rats and normal rats.Results showed that after treatment with glipizide, fasting blood glucose levels were significantly decreased in both STZ rats (P<0.05) and normal rats (P<0.01), whereas fasting insulin levels kept unchanged in both groups; the number of hepatocyte insulin receptors were markedly increased in both STZ rats (P<0.05) and normal rats (P<0.01), but no difference was found in affinity constant of receptors in both groups. The results of our experiment indicate that glipizide potentiates insulin action by increasing insulin receptor concentration.更多还原