【摘要】 对1986年诊断的432例糖耐量减低(IGT)者,于1988年进行复查,IGT每年约7.7％发展为糖尿病(DM)。原空腹及服糖后1、2小时血糖较高的IGT者易发展为DM,可能为长期胰岛素抵抗,胰岛对持续高血糖刺激分泌胰岛素的功能失代偿所致。原血糖较低及控制体重的IGT者易恢复正常,并显示胰岛素抵抗减轻及胰岛素分泌功能改善。IGT者转为DM及正常组后血压降低,可能与血浆胰岛素水平降低有关。更多还原

【Abstract】 Four hundred and thirty-two subjects with impaired glucose tolerance (IGT) diagnosed in 1986 were re-examined in 1988. The incidence of diabetes in persons with IGT was 7.7% each year. IGT subjects with higher fasting, 1h and 2h pksma sugar levels after glucose load had higher incidence of diabetes, which may be due to persistent insulin resistance and decompensation of islet cell function to persistent stimulation of higher plasma glucose. IGT persons with lower plasma glucose levels and well controlled body weight tented to revert to normal oral glucose tolerance and manifested decreased insulin resistance and improved function of islet cells. The decrease of blood pressure in subjects with normal oral glucose tolerance reverting from original IGT may be related to lowered plasma insulin levels.更多还原