节点文献
用球形结晶技术改善甲苯磺丁脲的溶出速率
Improvement of dissolution rate of tolbutamide by the spherical crystallization technique
【摘要】 用球形结晶技术将难溶性药物甲苯磺丁脲在羧甲基纤维素钠(CMC—Na)的溶液中制成球形结晶聚集体(简称球晶)。用扫描电镜法观察到原药结晶为棱状结晶,而球形结晶为小片状及小梭状结晶的聚集体。用粉末X线衍射谱检测了球晶与原晶,发现衍射峰有不同之处,说明有部分晶型发生改变。其球晶的溶解过程由Hixson—Crowll方程式描述,溶解比原药快。
【Abstract】 Poorly soluble crystals of tolbutamide were modified in the presence of a sodi-um carboxymethyl cellulose by the spherical crystallization technique. The objec-tive is to improve the dissolution rate and to transform platelet crystals into sp-herical agglomerates.The dissolution process was described in terms of the Hixson-Crowell equation. The dissolution rate of the agglomerate was faster than that ofconventionally crystallized tolbutamide. Therefore, the solubility and flowabilityof tolbutamide can be improved in using the spherical crystallization technique.
【Key words】 spherical crystallization technique; tolbutamide; dissolution rate;
- 【文献出处】 中国医院药学杂志 ,Chinese Journal of Hospital Pharmacy , 编辑部邮箱 ,1991年11期
- 【被引频次】2
- 【下载频次】174