节点文献
氟啶酸在健康人体内药动学研究
Pharmacokinetic Study on Enoxacin in Healthy Chinese Volunteers
【摘要】 本文用尿药浓度法,研究了6名志愿者单剂量口服氟啶酸片、胶囊剂后的药物动力学。结果表明,氟啶酸片剂,胶囊剂具有相同的药物学特征及生物等效性。其药动学参数分别是:k(hr-1):0.1048、0.1039;t1/2(hr):6.92,7.08;Au0-42(mg):460.78,462.51;排泄率:76.80%,77.09%。氟啶酸片的相对生物利用度为99.62%。
【Abstract】 The concentration of enoxacin in urine of six healthy chinese volunteers wasdetermined after the tablet or the capsule was orally given by single-dose. thepharmacokinetic parameters were calculated from the urine drug concentration cur-ves the result showed that the parameters of enoxacin tablet and capsule were K(hr-1) 0. 1048,0.1039; t1/2(hr)6.92, 7.08; Au0-24(mg)460. 78,462.51 and eliminative ra-te(cumulative)6.80%,77.09% respectively. the relative bioavailability of the tabletwas 99.6%
- 【文献出处】 中国医院药学杂志 ,Chinese Journal of Hospital Pharmacy , 编辑部邮箱 ,1991年01期
- 【被引频次】1
- 【下载频次】7