【摘要】 本文用尿药浓度法,研究了6名志愿者单剂量口服氟啶酸片、胶囊剂后的药物动力学。结果表明,氟啶酸片剂,胶囊剂具有相同的药物学特征及生物等效性。其药动学参数分别是:k(hr^-1):0.1048、0.1039;t1/2（hr）:6.92,7.08;Au^0-42（mg）:460.78,462.51;排泄率:76.80%,77.09%。氟啶酸片的相对生物利用度为99.62%。更多还原

【Abstract】 The concentration of enoxacin in urine of six healthy chinese volunteers wasdetermined after the tablet or the capsule was orally given by single-dose. thepharmacokinetic parameters were calculated from the urine drug concentration cur-ves the result showed that the parameters of enoxacin tablet and capsule were K(hr^-1) 0. 1048,0.1039; t1/2（hr）6.92, 7.08; Au^0-24（mg）460. 78,462.51 and eliminative ra-te（cumulative）6.80%,77.09% respectively. the relative bioavailability of the tabletwas 99.6%更多还原