【摘要】 利福喷丁(R-773)临床主要用于治疗结核、麻风等疾病。本文对R-773进行了动物实验,结果发现其对肝药酶有诱导作用。大鼠肝微粒体蛋白、细胞色素P-450与空白对照组相比有明显的升高。经t检验有显著性意义(P<0.05),且能缩短大鼠戊巴比妥钠的催眠时间。与空白对照组相比有显著性意义(P<0.01)。更多还原

【Abstract】 Rifapentine (R-773), an antimycobacterialdrug is chiefly used in the treatment of tuberculosisand leperosy, ete. R-773 was used in rats, and theresults showed that the drug had induction action onhepatic metastases in contrast to the controls. Hep-atic microsome proteins and cytochrome P-450were significantly increased (P<0.05: t test),and the hypnotic time of sodium pentoborbital onrats was significantly shortened (P<0.01).更多还原