【摘要】 本实验用旋转蒸发法制备包裹胞壁酰二肽（MDP）的大多层脂质体（MLV）。⁵¹Cr释放实验和体内抑瘤实验表明,脂质体包裹的MDP（MLV-MDP）能在体外激活小鼠腹腔巨噬细胞的肿瘤杀伤活性;在体内延长荷瘤小鼠的生存时间。而相同剂量的游离MDP,空白脂质体及空白脂质体与游离MDP联合使用,既不能在体外激活巨噬细胞的肿瘤杀伤活性,也不能在体内延长荷瘤小鼠的生存时间。更多还原

【Abstract】 In this experiment, rotatory evaporation method was used to prepareliposomes containing MDP. Electron micrograph showed that the liposomesbelonged to large multilamellar liposomes and could interact with macrophages.⁵¹Cr release test and antitumor test in vivo showed that the liposome encap-sulated MDP （MLV-MDP） could activate mouse peritoneal macrophages totumoricidal state and prolonged the survival duration of tumor bearing mice.Preliminary discussions are presented about the preparation of liposomes, themechanisms of liposome-macrophage interaction, the properties of MLV-MDPto activate macrophages and the half-life of liposomes, etc.更多还原