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细菌内毒素与胆石症关系的探讨——胆石、胆汁中内毒素含量的测定

THE STUDY OF RELATIONSHIP BETWEEN BACTERIAL ENDOTOXIN AND CHOLELITHIASIS:THE DETERMINATION OF THE CONTENT OF ENDOTOXIN IN GALLBIADER, BILIARY DUCT STONE AND BILE

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【作者】 吴硕东陈淑珍余云夏云张铭连刘金钢陈跃新

【Author】 Wu Shoudong, et al Dept of Surgery, The Third Affiliated Hospital

【机构】 中国医科大学附属第三医院外科中国医科大学附属第三医院外科

【摘要】 应用显色基质法,对胆石症患者的结石,胆囊和胆管胆汁的内毒素含量进行了定量并与对照组胆囊胆汁做了比较。发现胆色素类结石内毒素含量显著地多于胆固醇类结石,胆石症患者胆囊和胆管胆汁内毒素也毒素也高于对照组胆汁。从而进一步证实细菌感染在胆色素类结石形成中的重要意义。作者提出细菌内毒素在胆色素结石发生过程中起着关键的作用。

【Abstract】 The content of endotoxin in gallblader, biliary duct, stone and bile fromcholelithiasis patients and gallblader bile in control group were determined byusing modified limulus lysate test (LLT) with chromogenic substrate, findingthat the content of endotoxin in calcium bilirubinate stone was obviouslyhigher than that in cholesterol stone. The level of endotoxin in gallblader andbiliary duct bi1e were both higher than those in control group. The aboveresults may further prove the significance of bacterial infection in the forma-tion of calcium bilirubinate stone the author suggests a new concept ofimportant role of bacterial endotoxin in the formation of calcium bilirubinatestone.

【关键词】 内毒素胆石症细菌
【Key words】 cholelithiasisendotoxinbacteria
  • 【文献出处】 中国医科大学学报 ,Journal of China Medical University , 编辑部邮箱 ,1991年02期
  • 【被引频次】1
  • 【下载频次】47
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