【摘要】 经强噪声重复暴露（96 dB,2h/d,25 d）后,幼年和老年大鼠在条件反应的建立和再建立过程中,其海马CA₃区习得性长时程突触增强（LTP）的发展均受到明显阻抑,相应地动物达到学会标准需更多的训练。但幼年鼠受阻抑的程度更为严重。对习得性LTP的消退则在幼年和老年大鼠均无明显影响。本研究从突触功能的可塑性方面揭示幼年功物特别容易受到强噪声重复暴露的危害,提示应重视环境噪声对人类婴幼儿脑功能的损害作用的研究。更多还原

【Abstract】 After repeated exposure to noise (96dB, 2 hours/day, for 25 days) in the young and aged rats, a disorder of development of the learning-dependent long-term synaptic potentiation (LTP) in the hippocampal CA3 region was found during the establishment and the re-establishment of conditioned drinking response. More training was needed to increase the amplitude of PS to the maximal level and to reach the criterion of acquisition in noise-exposed animals than the control animals. These changes are more serious in the young animals than in the aged. There was no significant difference in the extinction of the learning-dependent LTP between the exposed rats and the control. The results indicate that the young rats are especially subject to the adverse effect of repeated exposure to noise on learning and memory function and, therefore, great attention must be paid to investigate the effect of exposure to noise on the higher function of infants’ brain.更多还原