【摘要】 本文报道两例神经型地克病尸检材料,阐述了对中枢神经系统和内分泌腺的病理形态学研究结果。首次描述地克病脑边缘系统病变的广泛性。指出脑各部形态变化,特别是边缘系统的形态变化,可能是脑发育和代谢障碍的结果。这种不可逆性变化,导致受中枢神经系统控制和调节的脑垂体及其靶器官的发育、代谢和功能障碍及形态变化。这正是不同类型克汀病患者临床表现的基础。更多还原

【Abstract】 2 autopsy cases of endemic cretinism (nervous type) are reported.The chang-es of the central nervous system and endocrine glands are emphasized.It is thefirst time to describe extensive pathological changes of the limbic system ofthe brain in endemic cretinism.The morphologic changes of the brain,especial-ly,of the limbic system,may be the consequence of cerebral dysplasis and dys-bolism.They lead to dysplasis,dysbolism,dysfunction and morphological chan-ges of hypophysis and its target organs in turn.All the above changes formthe basis of the clinical features of different types of patients with cretinism.更多还原