【摘要】 臭冷杉精油对急慢性炎症,Ⅱ、Ⅳ型变态反应和佐剂关节炎均有明显抑制作用,抑制白细胞游走,抑制PGE的合成或释放,抑制PGE、组胺、5-HT等炎症介质的致炎作用,对自由基的产生亦有明显抑制作用。更多还原

【Abstract】 The essential oil of Abies nephrolepis (Trautv.) (ANEO) noticeably reduced the conten of PGE in the exudate formed after injecting carrageenin into rat’s hind paw, the content of malondialdchy de (MDA)in hepatic tissue of alcohol intoxicated mice, and increased the activity of catalase (CAT) in hepatic tissue of mice and the activity of superoxide dismutase (SOD) in rat serum.It had no apparent effect on the swellieg of the rat’s hind paw induced by injecting mycostatin, the content of acid phosphatase in the exudate.When ANEO was ig administcred before and after sensitination, it had certain inhibitory cllect upon Arthus reaction; bowever, when it was administered before challenge, Artbus reaction was obviously inhibited. It had significant suppressive effect on reversible passive Arthus reaction and adjuvant arthritis. The delayed hypersensitivity reaction induced by tuherculin in rats was distinctly suppressed by administration of ANEO both before and after sensitization and challege. ANEO had no apparent effect on the content of immune complex in serum of rats with Arthus reaction.Conclusion: Expermental results indicate that ANEO had marked suppressive effect on acute, chroinc, immune inflammation and the mechanism of antiinflammatory effect of ANEO is rather complicated.更多还原