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龙牙楤木总甙的抗缺氧作用
Anti-anoxia Action of Total Aralosides
【摘要】 龙牙楤木总甙一次给药(灌胃或腹腔注射),有显著的抗缺氧作用,降低耗速度;对小鼠脑和心肌缺氧有明显的保护怍用。对KCN和NaNO2引起的组织中毒性缺氧也有明显的解毒作用。血气分析显示,其可使PAO2显著升高,加大动-静脉氧分压差(PA-VO?),增加供氧。
【Abstract】 A single ig or ip injection of total Aralosides to mice showed significant antianoxia action in a dose-dependent manner. It markedly reduced the rate of oxygen, consumption and significantly prolonged the time of breathing suspension and the time of inspiration stop induced by iv air in mice, It had an obvious protective effect on anoxia in brain induce by ligating bilateral carotid, decapitating and in heart induced by ip ISO and on poisoning anoxia induced by ip KCN and NANO2 in mice. The analysis of blood gas in rabbits showed that aralosides markedly raise PAO2, augmented arerio-venous partial pressure difference of oxygen and increased oxygen supply.
- 【文献出处】 中草药 ,Chinese Traditional and Herbal Drugs , 编辑部邮箱 ,1991年03期
- 【分类号】R285.5
- 【被引频次】22
- 【下载频次】27