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铬对增强心肌细胞抗病毒作用的研究

Exprimental Study on the Anti-Viral Effect of Myocardial Cell Enhanced by Chromium Chloride

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【作者】 董杰德; 张爱萍;

【Author】 Long Jie-de(Dept.of Microbiology, Shandong Medical University, Jinan 250012) Zhang Ai ping(Institute of Endemic Diseases, Shandong, Jinan 250012)

【机构】 山东医科大学微生物学教研室; 山东省地方病研究所 济南 250012; 济南 250012;

【摘要】 本文研究了Coxsackie B2病毒(XOX B2V)对人及鼠心肌细胞的感染性以及三氯化铬对心肌细胞生长与对病毒感染佳的影响。实验结果证明人心肌细胞对COX B2 V感染的敏感性比鼠心肌细胞高。三氯化铬能促进人与鼠心肌细胞的生长,促进鼠心肌细胞的搏动及搏动频率加快,并随着培养时间的增加,细胞生长代谢旺盛,细胞培养液中乳酸脱氢酶(LDH)的含量升高。用含铬培养液培养的人心肌细胞对病毒感染的敏感性有所降低,人心肌细胞培养液中LDH的含量随病毒对细胞损伤的程度而升高。

【Abstract】 In this paper, we studied the infeetivity of Coxsackie B2 Virus(Cox B2 V) on human and rat myocardial cells (HMC and RMC) and the effect of chromium chloride(CrCl3) on growth heart cells and infectivity of the virus.Results indicated that HMC is more sensitive to the virus than RMC. Crcl3 could promote the grawth and pulsation of HMC and RMC.LDH studies of the cuhure cells revealed that:1. In cultured RMC treated with CrCl3, lactodehydrogenase (LDH) increased with the time of incubation.2. Sensitivity of the cultured cells treated with CrCl3 to Cox B2V decreased.3. In cultured HMC, LDH increased with the degree of CPE.

  • 【文献出处】 病毒学杂志 ,Virologica Sinica , 编辑部邮箱 ,1991年01期
  • 【被引频次】3
  • 【下载频次】26
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