【摘要】 本文通过凝固浴成球法,制备了颅通定/壳多糖药物缓释小球。考察了颅通定/壳多糖配比、交联剂、壳多糖分子量等因素对制剂药物含量和溶出速度的影响。结果表明,含药量56.7%的缓释小球,在模拟胃、肠液中,T₅₀分别可达40min和180min;全部溶出时间可达9h和12h。更多还原

【Abstract】 The paper described a delivery system prepared from granulation of a chitosan solution containing rotundine in a coagulating bath and examined the effects of the ratios of rotundine: chitosan, crosslinking agents and molecular weight of chitosan on the analgesic release rate. It was shown that the rotundine （56.7%） -chitosan （Mw :5.70×10⁵ degree of deacetylation: 72.4%）gelled granules in an artificial gastroenteric juice （pH 1.0 and 7.2 ） have T₅₀ of 40 and 180 min respectively, and the total release time sustained over 540 min.更多还原