【摘要】 <正> 粉花石斛Dendrobium loddigesii Rolfe的茎为常用中药石斛的品种之一,具有滋阴清热、生津益胃、润肺止咳等功效,其化学成分未见研究报道。本文从粉花石斛鲜茎中分得3个化合物,分别鉴定为石斛宁定(shihunidine)、石斛宁(shihunine)和石斛酚(dendrophenol),其中石斛宁定为新化合物,经化学反应证明,石斛宁定是由石斛宁产生的非天然产物。石斛宁定和石斛宁具有强的抑制大鼠肾脏微粒体Na~+,K~+-ATP酶活性的作用。更多还原

【Abstract】 According to IR, UV, MS and NMR spectra of the compounds isolated from the fresh stem of Dendrobium loddigesii Rolfe (a Chinese medicine), 3 constituents were identified. They are shihunidine, shihunine and dendrophenol (4, 4 ’---dihydroxy -3, 3’, 5- trimethoxybibenzyl). Chemical reactions showed that shihunidine was derived from shihunine during isolation. Shihunidine and shihunine were shown to be inhibitors of Na~+, K~+ - ATPase of the rat kindney.更多还原