【摘要】 <正> 青蒿素(1)是从青蒿(Artemisia annua)中分离得到的一个抗疟化合物。青蒿素的发现改变了以往抗疟药物均为含氮杂环化合物的格式,开创了一类以过氧化合物为特征的、对抗氯喹虫株有效的新型抗疟药物。七十年代青蒿素结构发表以来,国内外在化学、药理以及临床方面均进行了大量工作,成为当今抗疟药方面最活跃的一个研究课题。这里简要报道更多还原

【Abstract】 Compound 3 （deoxoqinghaosu）and compound 4 （deoxocarbaqinghaosu） were synthesized from arteannuic acid （2）. Primary exploration of their antimalarial effect against K₁₇₃ strain of Plasmodium berghei shows that compound 3 is somewhat more effective than the natural compound—— qinghaosu.However, the carba-analogue compound 4 is almost ineffective. The enhanced activity of compound 3 is supposedly ascribed to its higher lipophilicity and, hence, higher affinity for plasmodial membrance. Further studies are in progress.更多还原