【摘要】 18β-甘草次酸钠ip 14mg/kg、21mg/kg使乏氧性缺氧小鼠的存活时间延长,小鼠的整体耗氧率降低,小鼠血液pH值提高,酸中毒减轻,也能使混合血的氧分压降低,但对小鼠血中甲状腺素含量无明显影响。更多还原

【Abstract】 The studies on the antihypoxia mechanism of 18β-SGA were reported. The survival time of hypoxia mice were longer than those of the control after intraperitoneal injections of 14mg/kg or 21mg/kg of 18β-SGA ( Sodium 18β-glycyrrenetic acid). Changes of various physiological indications after administration of the drug were as follows: blood pH was risen; acidosis was relieved; and the partial pressure of oxygen in the mixed blood was decreaed. The blood thyroxine level remain unchanged. It suggests the utilization of oxygen by the tissues was strengthened.更多还原