【摘要】 胃复安（MCP）30～100μmol/L能抑制豚鼠心室乳头状肌收缩力和肾上腺素诱发的自律性,降低兴奋性,延长功能不应期。此外,对豚鼠右心房收缩力和自律性有抑制作用。麻醉开胸犬iv MCP5mg/kg立即出现HR减慢,SBP,DBP,MAP,LVSP,CI,dP/dt_max和TPR增加;iv 10mg/kg MCP后,除CI仍增加外,上述各参数均降低;ivMCP5～10mg/kg对V_（?）e～+dP/dt_max和T值无显著影响。更多还原

【Abstract】 The effects of metoclopramide( MCP ) on the physiologic properties of guinea pig papillary muscles and the hemodynamics in anesthetic dogs were studied. MCP decreased contractility, increased the epinephrine concentration inducing automaticity and shifted the voltage-time plot to the right. But the functional refractory period was prolonged. Furthermore, the contractility and automaticity of the right auricle were decreased. MCP 5 mg/kg iv increased cardiac index (CI), systolic blood pressure ( SBP ), diastolic blood pressure ( DBP ), left ventricular systolic pressure ( LVSP ), maximal rate of change of intraventricular pressure ( dP/dtmax ), and total peripheral resistance ( TPR ) while MCP 10mg/kg iv decreased SBP, DBP, LVSP, dP/dtmax and TPR except increase of CI.更多还原