【摘要】 小鼠iv〔¹⁴C〕吗丙嗪3.7×10⁵Bq/20g（5.62×10⁷Bq/g）后0.5h的整体放射自显影中,以S₃₇肿瘤组织、肾脏,膀胱内和脊椎内的放射活性较高;皮肤、肺、肝、胃肠道及血管内较少。3h时除肿瘤组织,肾脏和胃肠道持续积聚外,其它组织均趋减少。12h只有肠道留有残迹,其它组织已无放射性。吗丙嗪在各组织内的分布与其疗效和毒性有关。更多还原

【Abstract】 Probimane was first synthesized and developed in Shanghai Institute of Materia Medica, Chinese Academy of Science as a novel antit umor agent. Male mice were injected iv 〔14C〕 probimane 3.7×105Bq/20g( 5.62× 107Bq/g ) . At 0.5h,higher radioactivities were found in S87 tumor, kidney, bladder, and vertebra, moderate in skim, lung, liver, blood vessel and gut. The radioactivities tended to decre-aseafter 3h except in the tumor, kidney, and gut in which radioactivities persisted. After 12h, only a trace of radioactivity was detected n intestine. The distribution of probimane correlated with its therepeutic efficacy and toxicity.更多还原