【摘要】 通过角叉菜胶诱发大鼠急性胸膜炎模型,发现im阿魏洛芬（FL,50～200mg/kg）能剂量相关性减少炎性渗出、抑制白细胞游走、降低渗液中的蛋白含量;大剂量FL200mg/kg还降低渗液中β-葡萄糖醛酸苷酶活性。体外实验显示FL(3.8～15×10^-5mol/L)可浓度依赖性抑制酵母多糖激活大鼠腹腔巨噬细胞释放H₂O₂。还发现无效浓度的异丙肾上腺素对FL的体外效应有协同作用。更多还原

【Abstract】 Anti- inflmmatory effects of ferulofen(FL)and its mechanisms were studied. In the rat carrageenin pleurisy, FL produced a dose-related reduction of exudate volume, protein contents and leucocyte numbers in the exudate. FL also reduced activity of β-glucuronidase in the exudate only in higher dose 3 h after carrageenin. These results suggest that FL has a marked anti-inflammatory action and its mechanisms may be similar to indomethacin. Ia vitro, FL caused a dose-dependent inhibition of hydrogen peroxide release from rat peritioneal macrophages ( M0 ) stimulated by opsonized zymosan. It suggested that its anti-inflammatory mechanisms may also relate to inhibitting cell activation. β-receptor agonist ( Isoproterenol, ISO), in a ineffective dose, synergized with FL in inhibitting M H2O2 release and the synergic mechanism remains to be established.更多还原