【摘要】 在对衰老动物垂体各内分泌细胞的胞核、核仁、线粒体及脂褐素和核质比进行立体定量分析研究的基础上,又对其激素合成与分泌的亚细胞结构进行研究。发现衰老时垂体各种内分泌细胞中粗面内质网、高尔基复合体和内分泌颗粒的Vv、Sv和Nv都有不同程度的增加或减少。在ACTH、LH/FSH细胞和TSH细胞中,粗面内质网的Vv、Sv随年龄的增长而减少,其中,LH/FSH细胞的高尔基复合体Vv、Sv和ACTH细胞的高尔基复合体Sv也同样出现年龄性降低.此外,GH细胞成熟或未成熟分泌颗粒Vv、Nv随年龄增长而有所增加;在PRL细胞中,成熟分泌颗粒Vv、Nv表现为增龄性增加,而未成熟分泌颗粒的Vv、Nv却反而减少。TSH细胞成熟分泌颗粒Vv增加,而未成熟分泌颗粒Nv和LH/FSH细胞的未成熟颗粒Nv却随年龄增长而减少.更多还原

【Abstract】 Besides the morPhometric changes of the organelles reported in the Previous Paper, the changes in synthetic and secretory organelles,including the changes of Vv, Sv and Nv of RER, Golgi complex and secretory granules, were investigated in aged rats. It was found that certain changes occurred with aging in all of the adenohypoPhyseal cells. The Vv and Sv of RER decreased with age in ACTH,LH/FSH and TSH cells, and so did the Vv and Sv of Golgi complex in LH/FSH cells and the Sv of Golgic complex in ACTH cells. In GH cells, the Vv and Nv in secretory granules increased with age; while in PRL cells, the Vv and Nv increased with age in mature granules but decreased in immature granules. The Vv of mature granules in TSH cells increased with age and the Nv o f immature granules decreased with age both in TSH and LH/FSH cells .更多还原