【摘要】 <正> 0 前言硝基苯乙酸是重要的医药和有机合成中间体,其经典合成方法常由于原料难得或使用毒性大的腈化物,给工业生产带来困难。G.Bottaccio等报道了对硝基甲苯在酚钠的存在下能和CO₂发生羧基化反应,得对硝基苯乙酸.所用溶剂为昂贵的六甲基更多还原

【Abstract】 An improvement on carboxylation agent to synthesizenitrophenylacetic acids has been worked out, in which sodium carbonates(or potassium carbonate) is used as a part of carboxylation agent. whenmole ratio-sodium phenolate: nitrotoluene(o-or p-) :sodium sarbonate(or potassium carbonate) attains 2:1:0.5, o-nitrophenylacetic acid yieldsin 82%, and p-nitrophenylacetic acid in 90%, if adding a little of tetra-butyl ammonium bromide at the same time.更多还原