【摘要】 本文报告了在四川省进行的一项鼻咽癌发病危险因素的配比病例对照研究。共调查鼻咽癌病人100名和按年龄、性别配对的其他病人与正常人300名。采用条件Logistic回归分析。结果鼻咽癌病人血清EB病毒VCA—IgA抗体阳性率达90.0%,几何平均滴度为1:76.16,均显著地高于对照组。常住四川省内、吸叶烟和食腌菜较多,亦为鼻咽癌发病危险因素。在单因素分析中,有鼻咽癌家族史者也有较高患鼻咽癌危险性,遗传度达77.24±7.22%,但经多因素分析结果不具有统计学显著意义。提示四川省的鼻咽癌发病危险因素可能以EB病毒感染和生活环境中的化学因素为主,而遗传易感因素的作用可能不象在鼻咽癌高发区那么重要。更多还原

【Abstract】 A matched case-control study on risk factors of nasopharyngeal carcinoma (NPC) was undertaken in Sichuan, China. One hundred cases of NPC diagnosted by biopsy and 300 age-and sex-matched controls were interviewed. Sera from all of the cases and controls were also collected to test IgA antibodies to Estein-Barr virus (EBV) capsid antigen(VCA). The positive percentage of VCA-IgA antibody of NPC cases was 93.0% and the geometric mean of titers(GMT) was 1: 75. 16. Both were higher than in the controls (P<0.001). The results of single factor Logistic regression analysis showed that a history of living in Sichuan province, tobacco smoking and salted vegetable consumption increased the risk for NPC. Firstgrade relatives of NPC cases also have a higher risk for NPC (OR=8.0, P<0.05)and the Hereditability (h~2) was 77.24±7.22%. Multiple Logistic regression analysis showed that living in Sichuan (OR=1.74, P=0.045), tobacco smoking (OR=6.87, P=0.001) and consumption of salted vegetable (OR=2.34, P=0.005) were risk factors of NPC. These results indicate that the etiology factors of NPC in Sichuan are mainly the infectious of EBV and environment chemicals. The role of heredodiathesis as a risk factor in Sichuan of NPC was probably not as important as it was in high-incidence regions.更多还原