【摘要】 本研究用大鼠背侧脊髓温育切片,观察了α₂肾上腺素能受体的活性对辣椒素（CAP）诱发P物质（SP）释放的影响。当灌流液中加入CAP（3μmol/L）后,SP释放增加4倍。CAP诱发的SP总释放率为0.45±0.1%,当应用α₂肾上腺素能受体激动剂可乐宁（10μmol/L）时,SP总释放率下降到0.25±0.02%（n=11,P<0.05）。育亨宾（100μmol/L）可拮抗可乐宁的效应。该结果提示,初级传入神经细纤维的中枢端的SP释放,受α₂肾上腺素能受体活性的调制。更多还原

【Abstract】 In the present study it was observed that thecapsaicin induccd the release of substance P （SP） fromthe slices of rat dorsal spinlal cord incubated in vitrowhich was inhibited by the activity ofx₂--adrenoreceptor. The relcase of SP was inercased 4 fold after the addi-tion of capsaicin （3 μmol/L） to the superfusion me-dium Total capsaicin cvoked SP relcase was 0.45±0.1%.It was reduced to 0. 25±0. 02%（n= 11, P<0. 05）whenthe x₂ --adrenoreceptor agonist clonidine （10μmol/L）was present Yohimbine （100μmol/L） antagomzed theclonidine effect. The results suggest that the releaseof SP from the central endings of primary small diame-ter afferent nerve was modulated by the activity ofx₂--adrenoreceptors.更多还原