【摘要】 为了探讨心肌梗塞（MI）后血浆性激素变化的方式和机理,本实验用放免法观察了MI前后不同时点的血浆性激素和皮质醇（CS）的演变。发现MI后急性期血浆睾酮（T）显著下阶（P<0.01）,雌二醇（E₂）轻度下降;恢复期血浆T和E₂都恢复;MI后血浆CS明显增高（P<0.05）,与血浆T呈相反变化;用T治疗的MI大鼠血浆CS无显著变化（P>0.05）。提示:MI后血浆性激素变化的重要原因是MI所致的应激反应,高浓度T可抑制MI后血浆CS的过度升高。更多还原

【Abstract】 To explore a mode and mechanism of the changesof plasma sexual hormones after myocardial infarction（MI）, the experiments were carried out in rats to measurethe plasma level of sex hormones and cortiol（CS）at a various phase of MI using a radio--immunologictechnique During the acute phase of MI, therestosterone（T） level reduced significantly（P<0.01）while the estradiol （E₂） level reduced slightly Follow-ing the recovery of MI, both T and E₂ levels rose to thecontrol levels. In addition, CS level increaseddramatically （P<0.05）, and its direction of changewas contrary to that of T. If the experimental rats withMI were treated with T, no change of CS level wasfound （P<0.05）. We conclude that the main reasonof the changes of a various sex hormones is due to thestress caused by MI, the administer of T could preventa elevation of CS更多还原