【摘要】 本文报道24例急性心肌梗塞患者发病24小时内血 TXB₂,6-K-PGF_1α,PRA 和ATⅡ的水平。与正常对照组比较,心梗组血 TXB₂,6-K-PGF_1α及 T/P 比值显著增加（P<0.01）,提示 TXA₂,PGI₂失衡的致病作用。而 T/P 比值改变可作为防治本病的参考指标。本文还观察到,心梗急性期血清 CPK 水平与血 TXB₂,T/P 比值无相关性（P>0.05）,而与6-K-PGF_1α呈正相关（P<0.025）。另外,同时测定 PRA,AT Ⅱ表明,在排除开搏通影响后（本文心梗患者中有13例服用开搏通,其血 PRA 较对照组显著升高,P<0.01,ATⅡ降低,P<0.025。11例未服用者血 PRA,ATⅡ均较对照组显著升高,P<0.01）,提示心梗急性期肾素——血管紧张素系统活性增加。更多还原

【Abstract】 The article reported the plasma levels of TXB₂,6-K-PGF_1α,PRA,and ATⅡ in24 cases were determined within 24 hours after AMI.Compared with controls,thelevels of TXB₂, 6-K-PGF_1αand T/P ratio were found significantly increased（P<0.01）.It was suggested that imbalance of TXA₂ and PGI₂ was pathogenesis to deve-lop AMI.The change of T/P ratio could be used as an indicator for prevention andtreatment of AMI.It was also showed that the level of serum CPK had no rela-tionship with TXB₂ and T/P ratio（P>0.05）,but had positive correlation with6-K-PGF_1α（P<0.025）.In addition,excluding the influence of Captopril,we demon-strated that the activity of Renin-Angiotensin System was critically increased inthe acutephase of AMI.更多还原