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诊断胶乳Ⅰ:可结合抗α-甲胎蛋白的胶乳微球的制备
Studies of Diagnosis Latex Ⅰ. Preparation of Latex Microspheres Available for Combining Anti α-Fetoprotein Ab
【摘要】 本文采用无乳化剂乳液聚合方法,实现了苯乙烯—甲基丙烯酸2-羟乙酯的共聚合,考察了亲水性单体对聚合速度和胶乳性能的影响,探索了胶乳微球结合抗α-甲胎蛋白的适宜条件,合成了可用于制备肝癌胶乳诊断试剂的单分散性好、表面“清洁”的胶乳微球。
【Abstract】 The latex microspheres ofstyrene/2-hydroxyethyl methacrylatecopolymers were prepared by meansof emulsifier-free emulsion polymeri-zation. It was indicated that thecontent of HEMA greatly affectedthe rate of polymeric reaction andthe average particle size. The surfaceproperty of latex microspheres wasexamined. Due to the clear surfaceand mono-dispersity of the latexmicrospheres, they were investigatedfor bonding anti-AFP Ab, andresulted that they could be usefulin the diagnosis of hepatoma.
【关键词】 无乳化剂乳液聚合;
胶乳微球;
苯乙烯;
甲基丙烯酸2—羟乙酯;
α—甲胎蛋白;
【Key words】 emulsion polymerization; latex, microsphere; styrene; 2-hydroxyethyl methacrylate; alfa fetoprotein;
【Key words】 emulsion polymerization; latex, microsphere; styrene; 2-hydroxyethyl methacrylate; alfa fetoprotein;
- 【文献出处】 生物医学工程学杂志 ,Journal of Biomedical Engineering , 编辑部邮箱 ,1991年03期
- 【被引频次】2
- 【下载频次】87