【摘要】 以音调结合气流刺激兔角膜的训练建立瞬膜条件反射,在条件反射率刚达90%,连续出现三组的学习初始阶段,电解损毁小脑半球第六小叶皮层使 D-I 核的学习相关性电活动和瞬膜条件反射消除,但不影响“非条件”反射,而在经一周巩固训练的动物,损毁小脑皮层上述区域不发生影响。D-I 核的细胞自发电活动在学习初期和记忆巩固时期也有所不同。在学习后期,D-I 核的细胞自发电活动频率减低,和在学习初期与损毁小脑皮层后的频率变化相似。实验结果表明:在瞬膜条件反射过程中,以小脑皮层为主导,对瞬膜条件反射的产生和D-I 核的学习相关性电活动具有调制作用。随着记忆巩固过程,D-I 核脱离皮层的控制而发展成为这一学习模式的记忆痕迹基础部位。更多还原

【Abstract】 Classical conditioning of the rabbit nictitating membrane(NM)response wasaccomplished by standard delay procedure of paired tone(CS)and airpuff(US)stimuli.Upon reaching a criterion of 90% conditioned responses(CRs)in 3 con-secutive blocks,an electrolytic lesion was made at the hemicerebellar Ⅵ corticallobule on the training side.Results showed that the learned response of the den-tate-interpositus(D-I)nuclei and the conditioned NM response were completelyor almost completely eliminated without affecting the unconditioned response.However,cerebellar cortical lesion performed on animals being over 1 week over-trained produced no effect on CRs and the learned response of the D-I nuclei.Meanwbile,the spontaneous activity of the D-I nuclei during consolidation reducedin frequency as a result of the cortical lesion at the early stage of learning.Our findings indicate that the cerebellar cortex plays a modulatory role in thegeneration of the conditioned NM response and the development of the learnedresponse of the D-I nuclei at an early stage of learning.With consolidation,theD-I nuclei become free of control from the cerebellar cortex and serve as the essen-tial component of the memory trace for this model system.更多还原