【摘要】 本工作观察了肝部分切除（68%）后96h 大鼠再生肝的抗 CCl₄损伤作用,并用氧电极法测定了再生肝线粒体的呼吸活性。结果如下: （1）CCl₄（50%,10ml/kg）引起的动物死亡率,肝切除组大鼠较假手术组明显降低;（2）CCl₄（50%,5 ml/kg）损伤后,肝切除组大鼠血清胆红素、血清谷丙转氨酶（sGPT）均明显低于假手术组,组织学检查损伤程度也明显减轻;（3）无论是否伴有 CCI₁损伤,肝切除组大鼠肝线粒体的呼吸活性均强于假手术组,且肝线粒体呼吸活性的变化与血清胆红素、sGPT 及肝组织损伤程度的改善是一致的。上述结果提示:再生肝线粒体呼吸活性增高,同时不易受 CCl₄损伤,可能在再生肝抗 CCl₄损伤机制中起一定作用。更多还原

【Abstract】 Protection of regenerating rat liver against carbon tetrachloride（CCl₄）poisoning 96 h after partial hepatectomy was observed,and the respiratory activityof its mitochondria was determined by using oxygen electrode method.Theresults were as follows:（1）Mortality in partial hepatectomized rats（PHR）causedby CCl₄（50%,10ml/kg）was reduced significantly as compared with sham oper-ated rats.（2）Following hepatic damage induced by CCl₄（50%,5ml/kg）,thelevels of serum bilirubin and sGPT in PHR were significantly lower than those insham operated rats.Histological examination of the liver also showed a significantexent of repair.（3）Respiratory activity of regenerating liver mitochondria inPHR with or without CCl₄ poisoning was higher than that in sham operated rats,and the respiratory activity went parallel with the degree of repairment of histo-logical damage,the reduction of serum bilirubin,sGPT and mortality.The resultsmentioned above indicate that increase of respiratory activity of regenerating livermitochondria and resistance to CCl₄ may play an important role in the protectionof regenerating liver against CCl₄.更多还原