【摘要】 1988年夏秋期间我市急性出血性结膜炎(AHC)病例明显增多。作者从124例 AHC 采得的201份眼拭标本中分离到124株病毒,阳性率为61.69%。新分离病毒为 RNA 病毒,病毒颗粒直径为27nm,具有肠道病毒的理化特征,对乳鼠有致病性,经血清学鉴定,确定为柯萨奇 A24型(CA24)病毒。新分离病毒代表株 SAHC1/88的抗原性与广州和武汉同年分离出的同型病毒相同,但与 EH24/70(新加坡)有一定差别。AHC 患者双份血清中和抗体滴度变动明显,恢复期 GMT 较急性期增加18.36倍,而健康人群中抗体水平甚低。以上结果表明,上海1988年 AHC 系由 CA24变异株引起,应用4种方法从10种药物中筛选出6种对 CA24病毒有抑制作用。更多还原

【Abstract】 The patients with acute hemorrhagic conjunctivitis(AHC)were found significantly in-creased in Shanghai during summer-autumn of 1988.124 of Coxsakie-virus A24(CA24)was isolated from 201 conjunctival swabs,indicating a positive rate of 61.69%.Thenewly isolated virus particles or virions consisted of ribonucleic acid(RNA).The size ofthe virus was 27 nm in diameter,and it had the physical and chemical characters ofentervirus.Antigenecities of CA24 isolated from Shanghai,Guangzhou and Wuhanspecimens in 1988 were identical,but they were different from EH24/70(Singapore).Titres of neutralizing antibody to CA24 in paired sera of the AHC patients showed significantdifference.Serum GMT in.the acute stage was 18.36 times higher than in the convalescentstage,while the titre of antibody in healthy population was very low.Furthermore scre-ening test for drug sensitivity revealed that 6 out of 10 drugs were found effective ininhibiting the growth of CA24 in tissue cultures.更多还原