【摘要】 本文用血清 T₃、T₄甲状腺激素¹²⁵I放射免疫试剂盒测定方法予以改良后用于唾液 T₃、T₄（ST₃、ST₄）测定。正常人 ST₃、ST₄值分别为0.057±0.022及2.05±0.78nmol/L.甲状腺功能亢进症（甲亢）患者 ST₃、ST₄值明显增高（P 均<0.001）。ST₃、ST₄与 T₃、T₄相关（P<0.05及<0.05）。ST₃、ST₄批内变异系数（CV）分别为2.42%、1.99%;批间CV14.14%、10.12%。唾液容量与结合率呈线性关系。结果表明 ST₃、ST₄能反映血清甲状腺激素水平,可作为一种非侵入性检测手段.更多还原

【Abstract】 Salivary triiodothyronine and thyroxine（ST₃ and ST₄）were measured with modifiedradioimmunoassay.ST₃ and ST₄ levels in normal individuals were 0.057±0.022nmol/L and2.05±0.78 nmol/L respectively.The levels of ST₃ and ST₄ in patients with hyrotoxicosiswere significantly higher than normal controls （both P<0.001）.ST₃ and ST₄correlated significantly with serum T3 and T4（P<0.01 and P<0.05 respectively）.Theintraassay coefficient of variations of ST₃ and ST₄ were 2.42% and 1.99%,and interassaycoefficient of variations were 14.14% and 10.12% respectively.There was linear correlationbetween the B/T binding rate and salivary volume.These results showed that determination of T₃ and T₄ in saliva can be used to estimate serum thyroid hormone levels.更多还原