【摘要】 本文报道106例母亲为双阳性(HBsAg、HBeAg)无症状携带者的健康新生儿,用等剂量的YHB疫苗和PHB疫苗,以同样的免疫顺序,作随机对照试验,分析两者对阻断母婴传播的效果。经2年观察,每6个月随访1次各期的保护效果,经卡方检验两组间无显著性差异,P>0.05。从发生乙型肝炎病毒感染来看,两组间亦无显著性差异。提示酵母菌提取的重组乙型肝炎疫苗与血源乙肝疫苗有同样的阻断母婴传播的效果,观察结果表明YHB疫苗用10μg也可获得好的保护效果。更多还原

【Abstract】 One hundred and six neonates born bo HBeAg-positive and HBsAg-carrier mothers were randomly divided into two groups, one receiving 20μg per dose of yeast derived hepatitis B vaccine (YHB vaccine) and another receiving 20μg per dose of plasma derived hepatitis B vaccine (PHB vaccine) on the day of birth at 1 month and at 6 months (three times). Physical examination and blood testing were performed for all infants at 6, 12, 18 and 24 months of age. Results showed that the protective efficacy rates at 6, 12, 18 and 24 months were 66.6%, 75%, 68.6% and 62.5% respectively for the YHB vaccine group and 57.7%, 75.5%, 61.2% and 51% respectively for the PHB vaccine group. During the 2 year follow-up period, 14 infants(25%) had serooonverted to HBsAg positiveness, 4 infants developed hepatitis B in the YHB vaccine group; 15 infante (29) had seroconverted to HBsAg positiveness in the PHB vaccine group, 6 of whom developed hepatitis B. The differences between the two groups wore not statistically significant by ohi-square test.The study indicates that YHB vaccine is comparable to and can replace PHB Vaccine for the prevention of mother-infant transmission of hepatitis B virus.更多还原