【摘要】 本文检测28名慢性迁延性肝炎患者及10名正常人的外周血单个核细胞(PB-MCs)内 HBV DNA 序列及其产生 IL-2的水平,以观察 HBV DNA 的存在和 IL-2产生二者之间的关系,以便探讨乙型病毒性肝炎的有关发病机理。结果发现慢迁肝患者PBMCs 产生 IL-2活性明显降低,降低的原因虽是多方面的,但 HBV 感染 PBMCs 可进一步导致 IL-2的活性降低,而后者又促进了 HBV 感染的慢性化,形成一种恶性循环。更多还原

【Abstract】 Peripheral blood mononuclear cells (PBMCs) were isolated from 28 patientswith chronic persistent hepatitis B (CPH) and 10 normal individuals for detectingHBV DNA and interleukin-2 (IL-2) .HBV DNA was found in the PBMCs from 9patients but was absent in 10 normal controls.IL-2 activities from both group withHBV DNA detected and group without HBV DNA detected were markedly decrea-sed in comparision with 10 controls (P<0. 01) IL-2 activity of PBMCs from groupwith HBV DNA detected was significantly lower than that of group without HBVDNA detected (P<0. 05) .The results indicate that the existence of HBV DNA inPBMCs is one of the causes of the decrease in IL-2 activity and that HBV inPBMCs is related to any specific or global defect in the function of them,thesemay play an important role on the immunopathogenesis of the disease such ascausing the process cryptoplasmically and chronically etc.更多还原