【摘要】 本文旨在研究口服单剂(5 mg及10mg)依那普利后动脉血压、心指数(CT)、外周血管阻力(PVR)、肺毛细血管嵌楔压(PCWP)的变化及其对血浆肾素活性(PRA)、血管紧张素Ⅰ,Ⅱ(AⅠ,AⅡ)水平,转换酶活性(ACEA)和血浆醛固酮(PA)、去甲肾上腺素(NE)、肾上腺素(E)浓度的影响。结果表明:(1)服药后12 h,血压、PVR,PCWP显著降低,CI 显著升高;(2)治疗后 PRA 及 AI 水平升高,AⅡ,PA,ACEA,NE,E 浓度均显著降低,说明典血液动力学作用与抑制肾素-儿茶酚胺的代谢有关,与剂量无明显相关。更多还原

【Abstract】 The purpose of this study is on the acute effects of enalapril on arterial blood pressure,cardiac index（CI）,peripheral vascular resista- nce（PVR）and pulmonary capillary wedge pressure（PCWP）.The plasma renin activity（PRA）,angiotensin Ⅰ,Ⅱ（AⅠ,AⅡ）,angiotensin conver- ting enzyme activity（ACEA）and norepinephrine（NE）and epinephrine （E）are monitored after given single dose of enalapril（5mg and 10mg）. The results show:（1）blood pressure is reducing significantly（from 16.0±1.4 to 13.6±1.3 kPa,P<0.01）,CI increasing（from 2.7±0.5 to 3.2±0.2 L/min/m²,P<0.05）,PVR and PCWP decreasing(from 2177± 824 to 1542±384 dyn·sec·cm^-5 and 2.2±0.9 to 1.2±0.9 kPa,P<0.01, respectively).（2）AII,ACEA,NE,and E are decreasing significantly after enalapril. The changes of these parameters suggests that the dose-independent and the hemodynamic effects of enalapril are related to its action on renin-ca- techolamine systems.更多还原