【摘要】 为探讨内皮素(Endothelin,ET)在败血症休克中均发病学意义,本工作在结扎大鼠盲肠并穿孔的晚期败血症模型上观察内皮素抗血清(ET-Ab)列败血症休克大鼠的治疗作用。结果发现,败血症休克大鼠血浆ET含量(放免测定)显著增加(77±1.4 vs假手术动物3.1±0.2pg/ml,p<0.01)。用特异的内皮素抗血清治疗明显降低血浆内皮素水平,改善休克动物的低血压、低血糖状态和组织细胞的损伤。结果证实,内皮素是败血症休克发病重要体液因素之一。更多还原

【Abstract】 In order to investigate the pathoge’netic role of endothelin in septic shock, the effect of endothelin-antiserum on septic shock was evaluated on late sepsis model ( 20h ) produced by cecal ligature and puncture ( CLP ) in rats. The results showed that ET level elevated significantly in septic rats (7.7±1.4 vs sham 3. 1±0.2, pg/ml p<0.01)and ET-antiserum administration ( 0.5ml ) dramatically reduced plasma ET level and alleviated tissue injury. It suggested that ET is an important humoral factor participating in the pathogenesis of septic shock.更多还原