【摘要】 用循环线性电流扫描计时电位法（CLC）、循环伏安法（CV）和微分脉冲伏安法（DPV）研究了五种胆碱类药物在水/硝基苯界面（W/NB）上的转移行为.在水相溶液呈碱性时,观察到了伴有不可逆水解反应的相转移过程.讨论了药物结构中的取代基效应,并依据离子转移的标准 Gibbs 能△_o^wG_tr^o 度量了取代基的疏水性效应及药物的脂溶性.更多还原

【Abstract】 Transfer behaviors across the water/nitrobenzene interface were studied for fivecholine derivatives by chronopotentiometry with linear ourrent scanning,cyclic voltam-metry and differential pulse voltammetry.The irreversible hydrolysis reactions coupledto the phase transfer of ions across the water/nitrobenzene interface were observed.TheGibbs energies of the transfer of choline derivatives show the effects of an additiveconstitution on hydrophobic property of the medicine.更多还原