【摘要】 二硫化四甲基秋兰姆（TMTD）是橡胶促进剂并广泛用作种子、水果、蔬菜的杀真菌剂。在鼠伤寒沙门氏菌试验中TMTD对TA₁₀₀及TA₉₈显示致突变活性,加入S₉致变活性增加,ICR小鼠骨髓微核试验表明,一次腹腔注入28mg/kg体重,多染红细胞微核率（MUPCE）显著增加,呈剂量-效应相关（r=0.939,P<0.01）。体外培养CHL,细胞的染色体畸变试验显示,染色体畸变率增至10—12%。 S.D大鼠致畸试验TMTD28,56,112mg/kg体重时,每窝活胎数明显减少,吸收胎,死胎率明显增加,并可见到四肢内翻,脑室扩人,心脏右移,肾移位等改变。研究表明,TMTD是一个致突变物及动物致畸物。更多还原

【Abstract】 Thiram (TMTD) is widely used as a vulcanization accererator for rubber products, and a fungicide for seeds, fruits, and vegetables. TMTD had mutagenic activities in Ames tests with S. Typhimurium strains TA100 and TA97, and S9 may enhance the mutagenic activity. The micronuclear test of the ICR mice showed that the frequencies of MUPCE were increased significantly by injecting intraperitoneally TMTD with the dose of 28 mg/kg bw. A dose-response correlation was seen (r = 0.939, P<0.01) . The rate ofchromosal aberration was 10-12%, using the cultured CHL cell in vivo.The teratogenicity test with S.D. rats on TMTD showed the decrease in vital fetus per litter, higher incidence of fetal resorption and death, bregma enlargment, retardation in ossification of occipital bone and cervical vertebra, and agenesis of the small ribs, using intubation into the rats. Changes of varus limbs, cerebral ventricle enlargement, right-shift of heart, and horizo-kidney were also seen. The results indicatel that the TMTD is a mutagen and a teratogen in animals.更多还原