【摘要】 用放射免疫法测定49例甲亢患者及30例正常对照组血浆心钠素浓度,发现甲亢患者血浆心钠素浓度明显高于正常对照组（P<0.01）,且血浆心钠素浓度与T₃、T₄、γT₃、心率呈正相关,与脉压差无相关。将甲亢患者分为他巴唑及利血平治疗组,结果提示他巴唑治疗组治疗后随着T₃、T₄、γT₃等甲状腺激素水平的下降,心率、心钠素水平也较治疗前显著下降（P<0.01）。利血平组治疗后在心率下降的同时,T₃、T₄、γT₃水平较前轻度增高,血浆心钠素浓度治疗前后变化不大（P>0.05）。更多还原

【Abstract】 Plasma concentrations of atrial natriuretic peptide （ANP） were measured in 49 hyperthy-roidism patients and 30 normal controls by radioimmune-assay. The plasma concentrations of ANP in thehyperthyroidism patients were significantly higher than those of the normal controls. Also, the plasmaANP concentrations were positively correlated with T₃、T₄、γT₃ and the heart rate, but not correlated with the pluse pressure. The patients were then divided into two groups randomly, and were given tapazol and reserpine respectively. In the tapazole--group the levels of T₃、T₄、γT₃、heart rate and ANP decreased re-markably （ P<0. 01）. In the reserpine group T₃、T₄、γT₃ increased, but the heart rate decreased, while the ANP concentrations did not change significantly （P>0. 05）.更多还原