【摘要】 该文研究人参茎叶多糖、田七多糖、绞股兰皂甙、白花蛇舌草煎液对补体及经CVF处理的豚鼠补体活性的影响,发现上述中药成分对正常豚鼠补体水平无明显影响,但对经CVF处理后的豚鼠低补体状态在连续给药5～8天后有一定促进恢复作用。给豚鼠腹腔注射50μg/kg的CVF,CH₅₀下降94％～97％,12天后才恢复正常。此时再次给予同样剂量的CVF,几乎不能再产生降补体作用,可能是由于已产生CVF抗体的缘故。用CVF造成动物低补体状态以研究某些中药成分的药理作用是一新的尝试。更多还原

【Abstract】 The effects of the polysaccharides separated from the stem and leaves of Ginseng（Panax ginseng C. A. Meyer）, from the root of Tianqi （Panax notogimeng （Burk） F. H. che-n）, and the Saponim from Jiaogulan （Gynostemma Pentaphyllum Makino）, and the aqua solu-tion of Baihua sheshe chao （Hedyotis diffusa Willd.） on the complement activity in normalguinea pigs and in CVF treated decomplemented guinea pigs were studied. The results revealedthat the above TCMC had little, or no effect on the complement level of normal guinea pigs,but could elevate the low complement level of CVF treated animals nearly normal level after5～ 8 days continuous administration of the above drugs. CH₅₀ decreased by 94%～97%when the guinea pigs were given ip 50μgCVF/kg body weight, and such decrement returnedto normal only after 12 days. At this time, the same dose of CVF could hardly deplete thecomplement content because of the production of anti-CVF Ab. This study is a new experi_mental opproach in which we have studied the immuno-pharmacology of some TCMC.更多还原