【摘要】 采用HPLC苦味酸内标法对8名健康志愿者单次口服0.6g甲硝唑进行唾液药代动力学分析。其药时曲线4名符合一室模型,4名符合二室模型,平均消除半衰期(t1/2β)为8.80±1.73h,峰药浓度(Cmax)为14.87±4.41μg/ml,达峰时间(tmax)为1.23±1.08h,曲线下面积(AUC)为178.48±65.50mg/l·h其中4名另单次口服0.2g甲硝唑,0.6g与0.2g的Cmax比值为3.56,接近剂量比值3.0,符合一级动力学吸收规律。更多还原

【Abstract】 Metronidazole saliva pharmacokinetics was studied aftersingle oral administration of 0. 6g in 8 health volunteers. Saliva concen-tration-time data were fit to a one-compartment model for 4 volunteers,but another 4 whose data required fitting to a two-compartment model.The mean elimination t1/2β was 8. 80± 1. 73h, tmax 1. 23± 1. 08h, Cmax 14. 87±4. 41 μg/ml, AUC 178. 48± 65. 5mg/l·h. 4 volunteers had another singleoral administration of 0. 2g. The Cmax ratio of 0.6g and 0.2g is 3.56 si-milar to dosage ratio 3. 0. This result accords with first order kineticsabsorbtion law.更多还原