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酰氨基硫脲及其相关杂环衍生物的研究(ⅩⅦ)——1-芳酰基-4-[4′-(2,2,6,6-四甲基哌啶)-1-氧]-氨基硫脲的合成
Studies on Acylthioscmicarbazides and Related Heterocyclic Derivatives (XⅦ)——Synthesis of Some l-Arylformyl-4-[4’-(2,2,6,6-Tetramethyl-Piperidine)-l-Oxy]Thioscmicarbazidcs Compounds
【摘要】 本文报道21种新的1-芳酰基-4[4′-2,2,6,6-四甲基哌啶)-1-氧]-氨基硫脲化合物(5a-u的合成,利用IR、MS和ESR谱确认了产品结构,讨论了IR、MS、ESR谱的性质,初步观察了5a-u对L7712白血病细胞的抑制作用。
【Abstract】 Twenty one 1-arylformyl- 4-[4’- (2, 2, 6, 6-tetramethyl-piperidine)-1-oxy] thiosemicar-bazides were synthesized. Their structures were ascertained. And the characters of IR, MS and ESR spectra were discussed. The results of the preliminary experiment show that compounds(S) possess an inhibiting activity on L7712-Lekemia cell.
【关键词】 酰氨基硫脲；
哌啶氮氧自由基；
抗癌活性；
【Key words】 Acylthiosemicarbazides； Piperidine nitroxide； Anticancer activity；
【Key words】 Acylthiosemicarbazides； Piperidine nitroxide； Anticancer activity；
- 【文献出处】 高等学校化学学报 ,Chemical Research In Chinese Universities , 编辑部邮箱 ,1991年08期
- 【被引频次】8
- 【下载频次】82