【摘要】 <正> 随着肿瘤光动力疗法(Photodynamic Therapy,PDT)的不断发展,出现了一系列新光敏剂,其中,meso-四-(取代苯基)卟吩衍生物是一类肿瘤选择性摄入率高、理化性质稳定的光动力敏化剂,近年来,作者设计并合成了一组meso-四-(取代苯基)卟吩衍生物,并初步观察了它们对细胞及小鼠移植瘤的光动力学效应,为了进一步比较不同卟吩衍生物的光敏化更多还原

【Abstract】 The ability of meso-tetrakis- (substituted phenyl) porphine derivatives for photo-generating singlet oxygen (1O2) is studied by ESR spectrometry. The results show that the singlet oxygen yields of most of porphine derivatives are higher than that of HPD. It is also exhibited that the nature and structure of the substituent at the meso position are closely related to the photosensitizing ability of meso-te-trakis-(substituted phenyl) porphines.更多还原