【摘要】 本文研究了季铵化聚对氯甲基苯乙烯的肝素化反应,提出了肝素分子与季铵化聚对氯甲基苯乙烯间平均离子键数目的计算方法。结果表明,随着肝素的用量或聚对氯甲基苯乙烯的季铵化程度的增加,肝素-聚对氯甲基苯乙烯中肝素的含量均增大,而肝素与季铵化聚对氯甲基苯乙烯间生成的离子键数目均逐渐减少,两者变化随肝素用量的增加最后都趋向恒定值。文章对肝素化反应的结果作了解释。更多还原

【Abstract】 In this paper the heparinization of quaternaryly-ammonized poly-p-chloromethyl styrene (QAP-p-CMS) is studied and a method for calculating the average number of ionic bonds between QAP-p-CMS and heparin molecule is put forward. It is shown that both the amount of heparin and the quaternaryly-ammonization extent of P-p-CMS make a great impact on the constitutional and structural aspects of HP-p-CMS. The raise of the amount of heparin or the quaternaryly-ammonization extent of P-p-CMS all makes the heparin content of HP-p-CMS increase and the amount of ionic bonds between heparin molecule and QAP-p-CMS decrease gradually. Finally, an explanation for the results of heparinization is suggested.更多还原