【摘要】 本文选取由单个小鼠乳癌分出的两种异质性细胞亚群66和67,研究其生长动力学和对X射线的放射反应。实验结果表明:两细胞祩在指数生长期(P)的放射敏感性相同,但在相对静止期Q,细胞的放射敏感性显著高于P细胞,其中66Q细胞比67Q细胞更为敏感。实验还分析了66与67细胞处于不同生理状态对放射反应的差别与细胞周期分布密切相关,但与坪区Q培养、pH和细胞密度无关。更多还原

【Abstract】 The radiation responses of two heterogeneous murine tumor lines invitro was studied at the time of X-irradiation. The proliferating （P-cells） 66 and 67cells displayed equal radiosensitives, however, the quiescent （Q） cells were considera-bly more radiosensitive than the P-cells, with the 66 Q being more radioresponsivethan the 67Q. A detailed analysis of the metabolic status vs cell-cycle age （i. e.,G₁ vs S-phase） indicates that the cell-cycle age was the predominat influencing fac-tor for radiation-induced responses. The data also showed that in the plateau phaseQ-cell cultures pH and cell density were not influencing factors.更多还原