【摘要】 复合蛇毒急性毒性实验,小鼠灌胃给药的 LD₅₀为121.45±0.22mg/kg 体重,腹腔给药的LD₅₀为1.23±0.06mg/kg 体重。大鼠长期毒性实验分别灌胃给药5,10及20mg/kg 体重,对照组给予等容积的蒸馏水,连续6个月。高剂量组5只动物死亡（12.5%）,并有两肺出血斑点。病理报告高剂量组有轻度心肌细胞浊肿、肝内胆管周围炎性变化,中、低剂量组无明显改变.高剂量组存活动物于停药30天后,各项指标及病理检查均正常。更多还原

【Abstract】 Present article reported the acute and chronic toxicity of the composite snake venoms（CSV）with antitumor activity of mice and rats.The acute toxicity was determined in mice,and the LD₅₀ ig was 121.45±0.22 mg/kg（121.22～121.67 mg/kg）.The LD₅₀ ip in mice was 1.23±0.06 mg/kg.The chronic toxicity was studied in rats.160 rats with both sexes were used and divided equally into four groups.One control group was given water 1ml/100g,ig.The other three groups were ig 5,10 and 20 mg/kg·d of CSV respectively for 6 months consecutively.The general activity and survival rate were observed and recorded.After withdrawal,the rats were sacrificed at different time and subjected to laboratory and pathological examination.The results showed that 5 rats died of toxicity in 20 mg/kg· d ig group,two of which exhibited lung haemorrhage.There was no obvious change in blood routine tests,GPT,creatinine and nitrogen of urea of the rats’ blood after 3 and 6 months dosing.The ECG records showed no change after CSV.The pathological examination in igh dosing group exhibited only light cloudy swelling in heart muscle cells and chronic inflammatory change around the chole ducts and lobular of liver.In the middle and low dosing groups no abnormal change was found.更多还原