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茶叶阻断胃癌高发区人体内源性N-亚硝基脯氨酸合成

INHIBITORY EFFECT OF GREEN TEA ON ENDOGENOUS FORMATION OF N-NITROSOPROLINE IN SUBJECTS FROM A HIGH-RISK AREA FOR STOMACH CANCER

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【作者】 徐国平宋圃菊

【Author】 Xu Guoping;Song Puju Department of Nutrition

【机构】 中国儿童发展中心北京医科大学营养与食品卫生教研室

【摘要】 本文观察了绿茶水提取物对胃癌高发区人群体内N-亚硝基辅氨酸合成的影响。结果显示4.65g绿茶提取物(含维生素C75mg)可完全阻断高危人群体内过高的N-亚硝基脯氨酸合成(P<0.01),其效果强于同量维生素C(P<0.01)。受试者不同程度的胃粘膜病变对上述阻断作用无明显影响(P>0.05)。

【Abstract】 Effect of green tea extract on endogenous formation of N-nitrosoproline (NPRO) in subjects froma high-risk area for stomach cancer was examined. The result showed that 4.65 g green tea extract(containing vitamin C 75 mg) completely inhibited elevated endogenous formation of NPRO in thesubjects (P<0.01) and the effect was better than that of the same dose of vitamin C (P<0.01). Thementioned inhibitory effect was not modified by severity of gastric mucosa lesions of the subjects (P>0.05).

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