【摘要】 本文以微核试验(MNT)为指标,诱变剂丝裂霉素C(MMC)为阳性对照物,评价了人参茎叶总皂甙(GNS)的抗诱变作用。结果证实,GNS无论腹腔注射或口服,无论大小剂量同时给予小鼠,均能降低MMC诱发的微核率。实验结果说明,GNS具有抗诱变作用。更多还原

【Abstract】 Ginsenosides from stem and leaves of Panax ginseng (GNS) was tested for its antimutation effect in mouse, using the micronucleus test (MNT) as the index, and mutagen mitomysin C as the positive control. No matter whether GNS was administered intraperitoneally or orally, the results showed that GNS did not induce micronuclei (MN) in mouse bone marrow cells. When GNS and MMC were administered simultaneously, the frequency of MN was much lower than that of the positive control. Obviously,GNS could reduce MN significantly. It is concluded that GNS was proved to have the effect of antimutation.更多还原